Thymosin Alpha-1

Thymosin Alpha-1

Price range: $42.00 through $65.00

For research purposes only. Not for human or animal use & not FDA-approved. By purchasing, you confirm you are 21 or older and qualified researcher.

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4 - 5 $37.80
6 - 9 $35.28
10 + $31.50
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Description

Thymosin Alpha-1 (Tα1)

Research-Grade Immunomodulatory Peptide
Tagline: Immune System & Inflammation Research

Product Description

Thymosin Alpha-1 (Tα1) is a 28–amino acid peptide fragment derived from the thymic hormone prothymosin alpha. It is a potent immunomodulatory molecule that enhances both innate and adaptive immune responses.

Researchers use Tα1 in preclinical and in vitro studies to explore immune activation, T-cell function, antiviral defense, and tumor immunology. It is widely studied for its potential to regulate immune tolerance, modulate cytokine production, and restore immune balance in immune-suppressed states.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Thymosin Alpha-1

  • Immune Activation: Enhances T-cell differentiation and NK cell activity.

  • Broad Research Relevance: Studied in infection, cancer immunology, and vaccine adjuvant research.

  • Cytokine Modulation: Promotes Th1 response, increases IFN-γ production.

  • Well-Characterized Peptide: Clinically investigated, with decades of published data.

  • Batch Verified: ≥98% purity, identity confirmed by HPLC and mass spectrometry.

Important Note

For laboratory and scientific research only. Not for human consumption, therapeutic, or diagnostic use.

Details

Chemical Formula C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Mass ~3108.3 Da
CAS Number 62304-98-7
Form Lyophilized peptide powder
Shelf Life 24 months (lyophilized)
Intended Use For preclinical and in vitro research only
Storage -20 °C (dry powder), -80 °C (after reconstitution)

Research

Research Applications

Immune System Stimulation

Tα1 enhances T-cell differentiation, dendritic cell maturation, and NK cell cytotoxicity in immune models [1].

Infectious Disease & Antiviral Research

Shown to boost immune response to viral infections, increasing IFN-α and IL-2 production [2].

Cancer Immunology

Investigated as an immune adjuvant to increase tumor antigen presentation and cytotoxic T-cell response [3].

Autoimmune & Immune Tolerance Studies

Reported to modulate regulatory T-cell activity, restoring immune balance in autoimmune models [4].

References

  1. Goldstein AL et al. (1981). Thymosin Alpha-1: Chemistry and Biological Activity. Ann N Y Acad Sci.
    https://www.sciencedirect.com/science/article/pii/S0196978110003384

  2. Wang FS et al. (2004). Thymosin Alpha-1 Enhances Antiviral Immunity in Chronic Infection Models. J Hepatol.
    https://europepmc.org/article/MED/15546254

  3. Garaci E et al. (2000). Role of Thymosin Alpha-1 in Tumor Immunology. Cancer Immunol Immunother.
    https://www.sciencedirect.com/science/article/pii/S0192056100000758

  4. Romani L et al. (2006). Thymosin Alpha-1 and Immune Regulation in Autoimmunity. Ann N Y Acad Sci.
    https://europepmc.org/article/MED/17495242

Mechanism of Action

Mechanism of Action (How Thymosin Alpha-1 Works)

  • TLR Pathway Activation: Binds to Toll-like receptors (TLR2, TLR9) on dendritic cells and macrophages, triggering innate immune activation [Goldstein 1981].

  • Th1 Immune Shift: Promotes IL-2 and IFN-γ production, enhancing cell-mediated immunity [Wang 2004].

  • Cytotoxic T-Cell Support: Increases expression of MHC class I/II molecules, improving antigen presentation [Garaci 2000].

  • NK Cell Potentiation: Boosts natural killer cell cytotoxicity and anti-viral response [Wang 2004].

  • Immune Homeostasis: Modulates Treg and Th17 balance, helping restore immune tolerance [Romani 2006].

References

  1. Goldstein AL et al. (1981). Thymosin Alpha-1: Chemistry and Biological Activity. Ann N Y Acad Sci.
    https://www.sciencedirect.com/science/article/pii/S0196978110003384

  2. Wang FS et al. (2004). Thymosin Alpha-1 Enhances Antiviral Immunity in Chronic Infection Models. J Hepatol.
    https://europepmc.org/article/MED/15546254

  3. Garaci E et al. (2000). Role of Thymosin Alpha-1 in Tumor Immunology. Cancer Immunol Immunother.
    https://www.sciencedirect.com/science/article/pii/S0192056100000758

  4. Romani L et al. (2006). Thymosin Alpha-1 and Immune Regulation in Autoimmunity. Ann N Y Acad Sci.
    https://europepmc.org/article/MED/17495242

Certificate of Authenticity

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