GHK-Cu (Raw) - 1g

GHK-Cu (Raw) – 1g

$39.00

For research purposes only. Not for human or animal use & not FDA-approved. By purchasing, you confirm you are 21 or older and qualified researcher.

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Description

GHK-Cu (Raw)

Research-Grade Copper Tripeptide-1 (Bulk Raw Material)
Tagline: Tissue Repair & Regenerative Signaling Research

Product Description

GHK-Cu (Copper Tripeptide-1) is a naturally occurring copper-binding tripeptide composed of Gly-His-Lys chelated with Cu²⁺. Supplied here as a raw bulk research material, GHK-Cu is widely studied for its role in tissue regeneration, extracellular matrix (ECM) remodeling, angiogenesis, and inflammatory regulation.

GHK-Cu is endogenously present in human plasma and increases at sites of tissue injury. In laboratory research, it is used to investigate fibroblast activation, collagen and elastin synthesis, wound repair cascades, oxidative stress modulation, and gene expression related to tissue remodeling and cellular aging.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose GHK-Cu (Raw)

  • Bulk raw format suitable for formulation, screening, and scale-up studies

  • Extensively studied copper peptide with broad regenerative research history

  • Key ECM signaling molecule in fibroblast and connective tissue models

  • Angiogenesis & vascular remodeling research utility

  • Supports oxidative stress and inflammatory pathway studies

  • ≥98% purity verified by HPLC/MS for reproducible experimental results

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Compound Name GHK-Cu (Copper Tripeptide-1)
Sequence Gly–His–Lys • Cu²⁺ complex
Chemical Formula C14H24CuN6O4
Molecular Mass ~401.9 Da (Cu-complex)
CAS Number 89030-95-5
Form raw
Intended Research Use ECM remodeling, tissue repair, angiogenesis, oxidative stress studies

Research

Research Applications

Extracellular Matrix Remodeling & Tissue Repair

GHK-Cu stimulates fibroblast proliferation and regulates collagen, elastin, and proteoglycan synthesis, making it central to studies of connective tissue regeneration and wound healing. It also modulates matrix metalloproteinases (MMPs) to balance tissue remodeling.

Angiogenesis & Vascular Support

Copper is a critical cofactor in angiogenic signaling. GHK-Cu enhances vascular endothelial growth factor (VEGF) expression and supports microvascular formation, enabling research into tissue oxygenation and repair dynamics.

Oxidative Stress & Inflammatory Regulation

GHK-Cu increases endogenous antioxidant enzyme activity while suppressing pro-inflammatory cytokines. These effects support investigations into oxidative injury recovery and inflammation resolution in epithelial and connective tissues.

Gene Expression & Cellular Aging Research

Studies show GHK-Cu influences the expression of hundreds of genes related to DNA repair, antioxidant defense, apoptosis regulation, and cellular longevity, making it relevant to aging and regenerative biology research.

References

  1. Pickart L, et al. (2018). The Effect of the Human Plasma Molecule GHK-Cu on Stem Cells, Tissue Repair, and Anti-Inflammatory Signaling. OBM Geriatrics.
    https://www.lidsen.com/journals/geriatrics/geriatrics-02-03-009

  2. Pickart L. (2008). The Human Tripeptide GHK and Tissue Remodeling. Journal of Biomaterials Science.
    https://pubmed.ncbi.nlm.nih.gov/18581587/

  3. Sen CK, et al. (2002). Copper-induced vascular endothelial growth factor expression and angiogenesis. American Journal of Physiology.
    https://journals.physiology.org/doi/full/10.1152/ajpheart.00518.2001

  4. Park JH, et al. (2016). Copper peptides and their role in skin regeneration and wound repair. Biomolecules & Therapeutics.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963000/

Mechanism of Action

Mechanism of Action

  • Copper delivery to repair enzymes: Acts as a bioavailable Cu²⁺ carrier for enzymes essential to tissue regeneration

  • Fibroblast activation: Stimulates fibroblast signaling and ECM component synthesis

  • ECM turnover regulation: Modulates MMPs and TIMPs to maintain balanced remodeling

  • Angiogenic signaling enhancement: Promotes VEGF-linked vascular growth pathways

  • Antioxidant defense upregulation: Increases SOD, catalase, and related antioxidant enzymes

References

  1. Pickart L, et al. (2018). The Effect of the Human Plasma Molecule GHK-Cu on Stem Cells, Tissue Repair, and Anti-Inflammatory Signaling. OBM Geriatrics.
    https://www.lidsen.com/journals/geriatrics/geriatrics-02-03-009

  2. Pickart L. (2008). The Human Tripeptide GHK and Tissue Remodeling. Journal of Biomaterials Science.
    https://pubmed.ncbi.nlm.nih.gov/18581587/

  3. Sen CK, et al. (2002). Copper-induced vascular endothelial growth factor expression and angiogenesis. American Journal of Physiology.
    https://journals.physiology.org/doi/full/10.1152/ajpheart.00518.2001

  4. Park JH, et al. (2016). Copper peptides and their role in skin regeneration and wound repair. Biomolecules & Therapeutics.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963000/

Certificate of Authenticity

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