AHK-Cu (Raw) - 1g

AHK-Cu (Raw) – 1g

$65.00

For research purposes only. Not for human or animal use & not FDA-approved. By purchasing, you confirm you are 21 or older and qualified researcher.

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Description

AHK-Cu (Raw) – 1 g

Research-Grade Copper Tripeptide-3 (Bulk Raw Material)
Tagline: ECM Remodeling & Follicle Biology Research

Product Description

AHK-Cu (Copper Tripeptide-3) is a copper-complexed tripeptide composed of Ala-His-Lys chelated with Cu²⁺. Supplied here as a raw bulk material (1 g), it is intended for laboratories conducting formulation development, dose-response studies, and large-scale in-vitro or preclinical research.

AHK-Cu peptide belongs to the copper-peptide family studied for extracellular matrix (ECM) remodeling, fibroblast signaling, angiogenesis, oxidative stress modulation, and follicular microenvironment activity. While structurally related to GHK-Cu, AHK-Cu is frequently investigated in dermal and follicular regeneration models where copper availability and peptide-mediated signaling are central variables.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose AHK-Cu (Raw)

  • Bulk quantity (1 g) for formulation, screening, and scale-up studies

  • Copper-peptide signaling model for ECM and tissue repair research

  • High chemical stability due to Cu²⁺ chelation

  • Suitable for dermal & follicular systems (fibroblast/keratinocyte interaction studies)

  • Supports angiogenesis pathway research via copper-dependent signaling

  • ≥98% purity (HPLC/MS) for reproducible experimental outcomes

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Compound Name AHK-Cu (Copper Tripeptide-3)
Sequence Ala–His–Lys • Cu²⁺ complex
Chemical Formula C15H26CuN6O4
Molecular Mass ~401.9 Da (Cu-complex)
CAS Number 126828-32-8
Form Lyophilized powder
Shelf Life 24 months (lyophilized, sealed)
Intended Research Use ECM remodeling, dermal repair, angiogenesis, follicle biology

Research

Research Applications

Extracellular Matrix Remodeling & Dermal Repair

Copper-peptide complexes regulate fibroblast proliferation and ECM turnover, increasing collagen, elastin, and proteoglycan synthesis during tissue repair. These mechanisms make AHK-Cu valuable in dermal regeneration and wound-healing models.

Angiogenesis & Vascular Remodeling

Copper is a critical cofactor in angiogenic signaling. Copper peptides stimulate vascular growth and microcirculation support, enabling research into oxygen delivery and tissue repair dynamics.

Hair Follicle Microenvironment Studies

Copper peptides are explored in follicular biology for their roles in ECM support, dermal papilla signaling, and perifollicular vascular activity. AHK-Cu serves as a tool to evaluate fibroblast–follicle interactions and copper-dependent enzyme systems.

Oxidative Stress & Inflammatory Modulation

Copper peptide systems upregulate endogenous antioxidant enzymes and suppress inflammatory mediators, supporting studies on oxidative injury recovery and inflammation resolution in epithelial tissues.

References

  1. Pickart L, et al. (2018). The Effect of the Human Plasma Molecule GHK-Cu on Stem Cells, Tissue Repair, and Anti-Inflammatory Signaling. OBM Geriatrics.
    https://www.lidsen.com/journals/geriatrics/geriatrics-02-03-009

  2. Pickart L. (2008). The Human Tripeptide GHK and Tissue Remodeling. Journal of Biomaterials Science.
    https://pubmed.ncbi.nlm.nih.gov/18581587/

  3. Søndergaard JN, et al. (2016). Copper-dependent regulation of angiogenesis and extracellular matrix remodeling. Biochemical Pharmacology.
    https://www.sciencedirect.com/science/article/pii/S0006295216301010

  4. Sen CK, et al. (2002). Copper-induced vascular endothelial growth factor expression and angiogenesis. American Journal of Physiology.
    https://journals.physiology.org/doi/full/10.1152/ajpheart.00518.2001

Mechanism of Action

Mechanism of Action

  • Copper-dependent fibroblast activation: Enhances fibroblast signaling and ECM component synthesis (collagen, elastin).

  • ECM turnover regulation: Modulates metalloproteinases and their inhibitors to balance remodeling during repair.

  • Angiogenic pathway stimulation: Copper availability supports VEGF-linked and repair-associated vascular signaling.

  • Antioxidant defense enhancement: Increases endogenous antioxidant enzyme activity, reducing oxidative damage.

  • Bioavailable copper delivery: Acts as a Cu²⁺ carrier to enzymes essential for tissue regeneration and cellular repair.

References

  1. Pickart L, et al. (2018). The Effect of the Human Plasma Molecule GHK-Cu on Stem Cells, Tissue Repair, and Anti-Inflammatory Signaling. OBM Geriatrics.
    https://www.lidsen.com/journals/geriatrics/geriatrics-02-03-009

  2. Pickart L. (2008). The Human Tripeptide GHK and Tissue Remodeling. Journal of Biomaterials Science.
    https://pubmed.ncbi.nlm.nih.gov/18581587/

  3. Søndergaard JN, et al. (2016). Copper-dependent regulation of angiogenesis and extracellular matrix remodeling. Biochemical Pharmacology.
    https://www.sciencedirect.com/science/article/pii/S0006295216301010

  4. Sen CK, et al. (2002). Copper-induced vascular endothelial growth factor expression and angiogenesis. American Journal of Physiology.
    https://journals.physiology.org/doi/full/10.1152/ajpheart.00518.2001

Certificate of Authenticity

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