FOXO4-DRI - 10mg

FOXO4-DRI – 10mg

$119.00

For research purposes only. Not for human or animal use & not FDA-approved. By purchasing, you confirm you are 21 or older and qualified researcher.

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Description

FOXO4-DRI – 10mg

Research-Grade Senolytic Peptide
Tagline: Cellular Senescence & Longevity Research

Product Description

FOXO4-DRI is a synthetic D-retro inverso peptide derived from the FOXO4 protein sequence. It is a specialized research tool used to study senescent cell apoptosis, cellular aging, and tissue regeneration mechanisms.

By selectively disrupting the interaction between FOXO4 and p53 in senescent cells, FOXO4-DRI triggers targeted apoptosis of senescent cells while sparing healthy cells — making it a central compound in senolytic and longevity research models.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose FOXO4-DRI

  • Senolytic Selectivity: Targets senescent cells via FOXO4–p53 pathway disruption

  • Longevity & Aging Research: Used to explore tissue rejuvenation and cellular clearance

  • Strong Preclinical Profile: Demonstrated restoration of tissue function in animal studies

  • Novel Mechanism: D-Retro-Inverso design increases stability and bioavailability

  • High Purity: ≥98% purity verified by HPLC/MS

Important Note

For laboratory and scientific research only. Not for human consumption, diagnostic, or therapeutic use.

Details

Compound Name FOXO4-DRI
Chemical Class D-Retro-Inverso Senolytic Peptide
Chemical Formula C180H260N52O55S
Molecular Mass ~4134 Da
Sequence d(Cys-Thr-Thr-Val-Ala-Ser-Lys-Gly-Lys-Met-Lys-Gly-Ser-Thr-Cys)
Form Lyophilized powder
Intended Research Use Cellular senescence, apoptosis, and longevity studies

Research

Research Applications

Senescent Cell Clearance (Senolytic Activity)

FOXO4-DRI disrupts the FOXO4–p53 interaction, causing apoptosis specifically in senescent cells. In mouse models, this led to restoration of tissue function, improved kidney health, and increased physical performance [Baar 2017].

Longevity & Aging Research

By clearing senescent cells (“zombie cells”), FOXO4-DRI enables studies into lifespan extension, stem-cell rejuvenation, and age-related degeneration, providing insight into regenerative biology [Baar 2017].

Tissue Regeneration & Repair

Animal data show improved fur density, normalized organ histology, and enhanced tissue repair kinetics, making FOXO4-DRI valuable in regenerative and anti-aging research [Toussaint 2017].

Inflammation & SASP Reduction

Clearance of senescent cells leads to reductions in SASP factors (IL-6, TNF-α, MMPs), allowing exploration of inflammatory pathways in aging and chronic disease models [de Keizer 2017].

References

  1. Baar MP et al. (2017). Targeted apoptosis of senescent cells restores tissue homeostasis in aging mice. Cell.
    https://www.sciencedirect.com/science/article/pii/S0092867417302286

  2. de Keizer PL. (2017). The Fountain of Youth by Targeting Senescent Cells? Cell.
    https://www.sciencedirect.com/science/article/pii/S0092867417302481

  3. Toussaint O, et al. (2017). Senescence and aging: the role of FOXO transcription factors. Biogerontology.
    https://link.springer.com/article/10.1007/s10522-017-9692-4

  4. Childs BG, et al. (2015). Senescent cells: an emerging target for diseases of aging. Nat Rev Drug Discov.
    https://www.nature.com/articles/nrd.2015.57

Mechanism of Action

Mechanism of Action

  • FOXO4–p53 Disruption: Blocks FOXO4 from sequestering p53 in the nucleus, inducing apoptosis in senescent cells [Baar 2017].

  • Selective Senolytic Effect: Targets cells with persistent DNA damage and senescence markers (p21, p16INK4a).

  • D-Retro-Inverso Peptide Design: Enhances stability, enzymatic resistance, and cellular penetration [Toussaint 2017].

  • Restores Tissue Function: Clearing senescent cells improves organ regeneration and reduces chronic inflammation.

  • SASP Suppression: Eliminates cells producing pro-inflammatory cytokines and matrix-degrading enzymes.

References

  1. Baar MP et al. (2017). Targeted apoptosis of senescent cells restores tissue homeostasis in aging mice. Cell.
    https://www.sciencedirect.com/science/article/pii/S0092867417302286

  2. de Keizer PL. (2017). The Fountain of Youth by Targeting Senescent Cells? Cell.
    https://www.sciencedirect.com/science/article/pii/S0092867417302481

  3. Toussaint O, et al. (2017). Senescence and aging: the role of FOXO transcription factors. Biogerontology.
    https://link.springer.com/article/10.1007/s10522-017-9692-4

  4. Childs BG, et al. (2015). Senescent cells: an emerging target for diseases of aging. Nat Rev Drug Discov.
    https://www.nature.com/articles/nrd.2015.57

Certificate of Authenticity

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