IGF-1 LR3 Product Description
Product Overview IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arginine 3) is a synthetic, recombinant analog of the naturally occurring IGF-1 protein, engineered for enhanced stability and potency in laboratory and research applications. This 83-amino-acid polypeptide features a key structural modification: a substitution of arginine for glutamic acid at position 3, along with a 13-amino-acid N-terminal extension. These alterations result in a significantly extended half-life—up to 120 times longer than native IGF-1—due to reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs). With a molecular formula of C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ and a molecular weight of 9,117.5 g/mol (CAS: 946870-92-4), IGF-1 LR3 is supplied as a lyophilized powder for reconstitution in sterile water, ensuring optimal handling in controlled experimental settings.
Key Features and Specifications
- Purity: >99% (HPLC-verified for research-grade consistency).
- Stability: Stable at room temperature for up to 3 weeks when lyophilized; recommended storage below -18°C desiccated, with reconstituted solutions viable at 4°C for 2–7 days.
Research Applications IGF-1 LR3 is widely utilized in in vitro and animal model studies focused on cellular proliferation, tissue regeneration, and metabolic processes. It acts as a potent agonist of the IGF-1 receptor, activating signaling pathways such as PI3K/Akt and MAPK to promote:
- Cell Growth and Division: Enhances proliferation in diverse cell lineages, including ectodermal (e.g., oligodendrocytes, motor neurons) and mesodermal (e.g., osteocytes, chondrocytes, muscle cells) types, supporting stem cell research and large-scale biopharmaceutical manufacturing.
- Tissue Repair Models: Investigated for anabolic effects in muscle, cartilage, nerve, liver, and skin regeneration, where it facilitates nutrient uptake, protein synthesis, and nitrogen retention in rodent models.
- Metabolic Studies: Explored for its role in glucose and fatty acid uptake, fat metabolism modulation, and potential counteraction of glucocorticoid-induced side effects like muscle wasting in experimental anti-inflammatory therapies.
- Aging and Longevity Research: Examined in bovine, porcine, and murine models for offsetting cellular aging, reducing inflammation, and mitigating conditions such as muscle atrophy or neurodegeneration.
This product is intended strictly for laboratory research use only, including in vitro testing and non-clinical experimentation. It is not approved or labeled for any other purpose. Handle with appropriate safety protocols, as it is for use by qualified professionals in controlled environments.
