5-Amino-1MQ 50mg(43.72mg)

5-Amino-1-Methylquinolin-1-ium (5-Amino-1MQ) CAS Number: 42464-96-0

5-Amino-1MQ is a selective, small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme involved in the methylation of nicotinamide and other structural analogs using S-adenosylmethionine (SAM) as the methyl donor.

This research-grade compound is valued in biochemical and cell-based studies for its potent NNMT inhibitory activity (reported IC₅₀ in the low micromolar to nanomolar range depending on assay conditions). By blocking NNMT, 5-Amino-1MQ modulates cellular SAM/SAH ratios and influences pathways linked to energy homeostasis, methyl sink regulation, and epigenetic control in various experimental models.

Key features

• Chemical formula: C₁₁H₁₁N₂⁺
• Molecular weight: 171.22 g/mol (cation)
• Appearance: Typically supplied as the iodide or chloride salt (off-white to pale yellow solid)
• High purity ≥98% (HPLC)
• Good aqueous solubility as the charged quinolinium salt
• Cell-permeable and suitable for in vitro and ex vivo applications

Intended strictly for laboratory research use only. Not for diagnostic, therapeutic, or food/cosmetic applications.